The prevalence of seizures in DS appears to peak in infancy and late in life. Seizures occur in 5–10% of children with DS [Pueschel et […]

Premature degenerative bone and joint disease in adults with DS is reported in the orthopaedic literature [Dacre and Huskisson, 1988; Olive et al., 1988]. Pain […]

Recurrent urinary tract infections (UTIs) are of particular concern in our population. UTIs were documented in more than 25% of DS adults, particularly those who […]

Both acute and chronic problems of the respiratory tract occur frequently in our population. Three of the individuals with documented congenital heart anomalies also have […]

Recurrent and chronic ear infections in noncommunicative adults often go undiagnosed and can lead to mastoiditis and hearing loss. Almost half of the DS adults […]

Previous reports confirm the high incidence of eye abnormalities in DS adults [Hestnes et al., 1991]. Normal ocular findings in DS adults are considered to […]

Frequently encountered and significant health concerns are summarised by organ system in Table II.-DISCUSSION Multiple health concerns are common in DS adults residing in Woodlands. […]

Thirteen of 38 of our DS adults were deceased. The mean age of death was 48.5 years (range, 32–67 years). In the middle-aged group, 4/18 […]